Levetiracetam Overdose: A Case Report and Literature Review
کد: G-1008
نویسندگان: Kaveh Bahrami ℗, Mohammad Shariati ©, Fateme Khodadadi
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
background
Levetiracetam is an anticonvulsant. Although its precise mechanism of action is unknown, levetiracetam does not appear to directly interact with the GABA system. We report an overdose with levetiracetam, including clinical effects.
Methods
We investigate a case report of levetiracetam overdose, detailing the clinical conditions and treatments administered. Finally, we review other case reports and highlight key findings based on the collective data.
Findings
Our case involved ingestion of 32 tablets of 1000 mg levetiracetam within half an hour. The patient presented approximately 2 hours later with weakness, balance disturbance, and blurred vision, while alert and oriented. Vital signs were blood pressure 105/65mmHg, a pulse of 63 , and oxygen saturation 96%. Based on available data and reported case studies, the patient received treatment including charcoal and intravenous fluids initially, followed by emergency dialysis and two sessions of hemodialysis. Despite developing lethargy and confusion between hours 8 and 16 post-ingestion, the patient's vital signs stabilized after a week and, upon psychiatric consultation, was transferred to psychiatric hospital.
Conclusion
There is no specific antidote for levetiracetam overdose. If necessary, attempts should be made to remove unabsorbed drug through vomiting or gastric lavage. General precautions to maintain the patient's airway are also taken. General supportive care includes monitoring vital signs and observing the patient's clinical status. Due to limited clinical data on levetiracetam overdose, most reported cases indicate mild and transient symptoms. However, serious cases have been documented. Ongoing surveillance is necessary to better understand the associated adverse effects of levetiracetam overdose.
Key words
overdose, levetiracetam,
