Ketoprofen alleviates seizure by downreregulating of nuclear factor kappa B gene expression in the male Wistar rats
کد: G-1043
نویسندگان: Atefeh Eshgevaryan ℗, Kiyana Rahimi, Mahyar Abdi, Saba Fallahi, Mobina Salehi, Narjes Askari, Saghi Hakimi Naeini, Vahid Azizi, Abdolkarim Hosseini ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
background
Seizure is characterized by abnormal behavior or a set of movements that indicate abnormal brain cell function. Activation of the transcription factor NF-kB is one of the factors influencing the occurrence of neuroinflammation. Ketoprofen (KP), a non-steroidal anti-inflammatory drug (NSAID), acts to reduce the expression of inflammation-related genes and inhibit NF-kB. In this study, the effect of KP on seizures induced by pentylenetetrazol (PTZ) in laboratory rats was investigated.
Methods
The rats were subjected to seizures with 60 mg/kg of PTZ and were randomly divided into four groups, each consisting of 5 rats (200-250 g): healthy control, untreated control (PTZ) which received saline 30 min before PTZ, and two treatment groups that received 1 and 10 mg/kg doses of KP intraperitoneally. The effect of KP on the expression of inflammatory NF-kB gene was then evaluated by Real-time PCR using brain cell samples.
Findings
The results demonstrated that the two groups receiving KP experienced a significant reduction in NF-kB gene expression compared to the PTZ group (P0.05).
Conclusion
These findings suggest that KP affect seizure by downregulation of inflammatory NF-kB gene and warrants further investigation in the context of reducing inflammation-induced seizures.
Key words
Ketoprofen, NF-κB, Seizure
