Prevalence screening of rs4570625 polymorphism associated with depression in patients with generalized epilepsy
کد: G-1037
نویسندگان: Marzieh Mohammadi ℗, Ali Mohammad Ahadi ©, Hoda Ayat
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
background
Epilepsy and depression are two of the most common neurological challenges in human societies. Several studies have confirmed the sharing of cellular, molecular and biochemical pathways related to these two disorders. In some cases, one of these two disorders may be considered as the cause of another. One of the most important pathways related to depression is the production of 5-hydroxytryptamine or serotonin, in which the role of the enzyme encoded by the TPH2 gene is key. The role of rs4570625 polymorphism, which causes the conversion of nucleotide G to A or T in the upstream regulatory region of this gene, has been proven in relation to depression.
Methods
In this research, acknowledging the many studies that have confirmed a deep relationship between depression and some cases of seizures, we investigated this polymorphism among patients with GTCS generalized epilepsy. The blood samples of the patients were collected after obtaining the consent and obtaining the code of ethics, and after DNA extraction, primer design for rs4570625 polymorphism and Tetra-ARMS method were analyzed.
Findings
The results showed the prevalence of about 23% of the above polymorphism among patients with epilepsy (P≤0.05, CI=95%, OR=2.21).
Conclusion
Undoubtedly, we cannot consider the presence of this polymorphism as the cause of seizures, but our results clearly emphasize the common border between depression and epilepsy. Paying attention to such studies and results may encourage the therapist and medical sector of the society to the need to design more accurate drug and treatment programs.
Key words
"Epilepsy"; "Depression"; "rs4570625"
